Glutathione is a tripeptide containing a γ-amide bond and a sulfhydryl group, which is composed of glutamic acid, cysteine and glycine, and is present in almost every cell of the body.

Glutathione helps maintain normal immune system function and has antioxidant, integrated detoxification properties. The sulfhydryl group on cysteine is its active group (so it is often abbreviated as G-SH), which is easy to combine with certain drugs and toxins, so that it has an integrated detoxification effect. Glutathione can not only be used in medicine, but also as the base material of functional food, which is widely used in functional food such as anti-aging, enhancing immunity, and anti-tumor.

Glutathione has two forms, reduced (G-SH) and oxidized (G-S-S-G), and reduced glutathione accounts for the vast majority under physiological conditions. Glutathione reductase can catalyze the interconversion between the two types, and the coenzyme of this enzyme can also provide NADPH for the alternative metabolism of pentose phosphate.

As an important regulatory metabolite in cells, GSH is not only the prosthetic group of glyceraldehyde phosphate dehydrogenase, but also the coenzyme of glyoxalase and triose dehydrogenase. Can activate a variety of enzymes, such as sulfhydryl (SH) enzyme-coenzyme, etc., thereby promoting carbohydrate, fat and protein metabolism. GSH molecule is characterized by active sulfhydryl (-SH), which is the most important functional group. It can participate in a variety of important biochemical reactions in the body, protect the sulfhydryl group of important enzymes and proteins in the body from being oxidized and inactivated, and ensure energy metabolism and cell utilization. At the same time, it combines with the free radicals in the body through the sulfhydryl group, which can directly reduce the free radicals to acidic substances, thereby accelerating the excretion of free radicals and resisting the damage of free radicals to important organs. Haddad et al. found that GSH was involved in the regulation of lipopolysaccharide-induced cytokine transcription and the regulation of I-KB/NF-KB signaling pathway. Armstrong et al found that the reduction of GSH content is a potential early activation signal of apoptosis, and the subsequent generation of oxygen free radicals promotes cell apoptosis.

At present, the preparation methods of GSH include solvent extraction method, enzymatic method, fermentation method and chemical synthesis method. At present, it is mainly extracted from culturing high-content GSH yeast (brewer/baker's yeast). Its technological process:

1. Clinical Drugs

   Glutathione drugs are widely used in clinic. In addition to using its sulfhydryl group to chelate heavy metals, fluoride, mustard gas and other toxin poisoning, it is also used in hepatitis, hemolytic diseases, keratitis, cataract and retinal diseases, etc., as a treatment or Drugs for adjunctive therapy. In recent years, Western scientists, especially Japanese scholars have found that glutathione has the function of inhibiting HIV.

   The latest research also shows that GSH can correct the imbalance of acetylcholine and cholinesterase, play an anti-allergic effect, prevent skin aging and pigmentation, reduce the formation of melanin, improve the skin's antioxidant capacity and make the skin glow. , GSH also has a good role in the treatment of corneal disease and improvement of sexual function

2. Anti-oxidize effect

   As an important antioxidant in the body, glutathione can remove free radicals in the human body; because GSH itself is susceptible to oxidation by certain substances, it can protect the sulfhydryl groups in many proteins and enzymes in the body from being harmful. Substances are oxidized to ensure the normal performance of molecular physiological functions such as proteins and enzymes; the content of glutathione in human erythrocytes is very large, which is of great significance to protect the sulfhydryl groups of proteins on the erythrocyte membrane in a reduced state and prevent hemolysis.

3. Food additives

   Adding glutathione to food can have unexpected effects:

• Adding it to the flour products can play a reducing role. It not only shortens the time of making bread to one-half or one-third of the original, but also greatly improves labor conditions, and plays a role in strengthening food nutrition and other functions.

• Add it to yogurt and baby food, which is equivalent to vitamin C and can play the role of stabilizer.

• Mix it into the fish cake to prevent the color from deepening.

• When added to meat products and cheeses, it has the effect of enhancing the flavor.

Glutathione is mainly used in various cosmetics, such as lotions, lotions, essences, masks, creams, etc.

Precautions: It is forbidden for those who are allergic to this product. Glutathione cannot be combined with vitamin B12, orotic acid (vitamin B13), menadione, calcium pantothenate, orotic acid, antihistamine preparations, sulfonamides and tetracyclines. Add to cosmetics, otherwise it will cause skin allergies.

• Packing specification: 25kg cardboard drum, inner village double-layer plastic bag.

• Storage method: Please place in a dry and ventilated place, avoid direct sunlight and high temperature.